Bill: I had an interesting interview with Doctor David Leonardi about longevity. Why isn't there just a longevity pill that would allow us to have our cake and eat it too, and still live longer?
David: You know, Bill, a year ago, I would have told you that that's a ridiculous question, but actually, in the last 15 months, there's been a pretty amazing discovery. There actually is a pill now that mimics many of the benefits of caloric restriction, and it's called Pre-NAD+. If your listeners Google this, you want to be careful and use a hyphen it's Pre-NAD like Nancy, Adam, David, and then use a plus sign at the end, it's Pre-NAD+. This is a compound that increases the levels of NAD in the nucleus of our cells. By doing so, it mimics the benefits of caloric restriction, which have been shown to to extend lifespan in every species it was ever tested in by about 20%. And, caloric restriction involves restricting calories by about 33% below what you would need for normal maintenance, so it's a very onerous lifestyle. As a result, for about 60 years, scientists have been looking at the bio-chemical pathways by which caloric restriction works, and Pre-NAD+ actually mimics that bio-chemical process by raising the level of NAD in the cells, and gives you many of the benefits of caloric restriction.
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